0000002809 00000 n 1Department of Pharmacy, Kyung Hee University Hospital at Gangdong, Seoul, Korea, 2Department of Clinical Nursing, University of Ulsan, Seoul, Korea. The therapeutic benefits of diltiazem in supraventricular tachycardias are related to its ability to slow AV nodal conduction time and prolong AV nodal refractoriness. Your doctor may occasionally change your dose. INTRODUCTION. Patients must be informed to report any changes in sensation, signs, or symptoms during the IV administration of any chemotherapeutic drug and to alert the healthcare professionals to early signs of extravasation. A defibrillator and emergency equipment should be readily available. - Secure the cannula during the administration of the drug. Drug classes: Calcium channel blocking agents, Group IV antiarrhythmics. These guidelines consist of following topics: basic knowledge about extravasation, extravasation management, and extravasation prevention. No evidence of impaired fertility was observed in a study performed in male and female rats at oral dosages of up to 100 mg/kg/day. %PDF-1.4 % - Once the needle is removed, apply pressure to the puncture site for about five minutes and elevate the limb. Vesicant extravasation:Leakage of a drug that causes pain, necrosis, or tissue sloughing. startxref eugia, Rx only NDC 55150-427-10 Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. Extravasation is a serious complication during patient care. * Irritant drugs can cause local pain and inflammation but rarely cause tissue destruction. Hypotension - Decreases in blood pressure associated with diltiazem hydrochloride injection therapy may occasionally result in symptomatic hypotension (3.2%). 0000030660 00000 n Store product under refrigeration 2 to 8C (36 to 46F). Discard unused portion. 0000000956 00000 n Follow all directions on your prescription label. Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiadylt ER, Tiazac. Some patients may maintain response to an initial rate of 5 mg/h. The following adverse reaction rates are based on the use of diltiazem hydrochloride injection in over 400 domestic clinical trial patients with atrial fibrillation/flutter or PSVT under double-blind or open-label conditions. I remember the case of the complication of extravasation in my patient in 1985 when I was an intern. 2.5-3.6 Extravasation: may cause tissue damage Do not flush Albumin 4.5% Infusion Normal blood volume: 1-2ml/min Hypovolaemia or shock: up to 1 L/hour Plasma exchange: up to Revised: April 2023, Rx only NDC 55150-425-01 Only 1 of the studies of diltiazem was in children. Cardizem and Infusion site extravasation - a phase IV clinical study of FDA data Summary: Infusion site extravasation is found among people who take Cardizem, especially for people who are female, 60+ old. endstream endobj 513 0 obj <. Please enable it to take advantage of the complete set of features! - Do not insert the cannula in the joints because it is difficult to secure, and neural damage and tendon injury can be caused if extravasation occurs due to vesicant drugs. If hypotension occurs, it is generally short-lived, but may last from 1 to 3 hours. An official website of the United States government. Diltiazem exhibits frequency (use) dependent effects on AV nodal conduction such that it may selectively reduce the heart rate during tachycardias involving the AV node with little or no effect on normal AV nodal conduction at normal heart rates. Subsequent intravenous bolus doses should be individualized for each patient.
Microsoft Data Centre Amsterdam, Articles D