(See Iron, oral under Interactions.). Monitor response to therapy by evaluating hematologic parameters (hemoglobin and hematocrit) and iron storage parameters (serum iron, total iron binding capacity, and percent saturation of transferrin). Careers. .14.8 g/dl General disorders and administration site conditions: chest pain, chest tightness, weakness, malaise, febrile episodes, chills, shivering, sterile abscess, atrophy/fibrosis (intramuscular injection site), brown skin and/or underlying tissue discoloration (staining), soreness or pain at or near intramuscular injection sites, swelling, inflammation. 0000010759 00000 n For all medical inquiries contact: 8600 Rockville Pike David McAuley, Pharm.D. Accessibility Following administration of Infed, circulating iron dextran is split by the cells of the reticuloendothelial system into its components of iron and dextran. It should be remembered that iron deficiency anemia will not appear until essentially all iron stores have been depleted. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 8.1 Pregnancy INFeD preparation: Administer by deep IM injection using a 2- or 3-inch, 19- or 20-gauge needle into the upper outer quadrant of the buttock only. Therefore, administration of subsequent test doses during therapy should be considered. Sv During all Infed administrations, observe for signs or symptoms of anaphylactic-type reactions. 2.Intramuscular Injection - PRIOR TO RECEIVING THEIR FIRST INFeD THERAPEUTIC DOSE, ALL PATIENTS SHOULD BE GIVEN AN INTRAMUSCULAR TEST DOSE OF 0.5 mL. 0000031965 00000 n Am J Kid Dis. I. The chemical stability after reconstitution has been studied: the solution is physically and chemically stable for 48 hours at 25C. In doses 500 mg, iron dextran plasma concentrations decrease exponentially with a half-life of about 6 hours. fBw2e5/6k&Dd:/7(lc\s56l<6E'0$tumU? W@mZ_$3ZwE]^ Large intravenous doses, such as used with total dose infusions (TDI), have been associated with an increased incidence of adverse reactions. 2021 Allergan. 0000009371 00000 n Advise patients that delayed reactions can occur and that these must be reported to their healthcare provider immediately [see Warnings and Precautions (5.2)]. To avoid injection or leakage into subcutaneous tissue, use Z-track injection technique (i.e., firmly push aside subcutaneous tissue over the site of injection before inserting the needle). The easiest-to-prepare dilute solution (iron dextran, benzyl alcohol, and sterile water for injection) was stable for three months; stability was greater when refrigerated. 0000009983 00000 n 0000010005 00000 n (See PRECAUTIONS: General.) Patheon Italia S.p.A. The need for chemical compatibility studies of subcutaneous medication combinations used in palliative care. 1989;23(4):197-207. doi: 10.1007/BF00451642. Advise patients to consult their healthcare provider should they start to show symptoms of acute kidney infection as Infed should not be used [see Warnings and Precautions (5.3)]. Attached to this memorandum is a copy of a package insert for iron dextran (Infed). It is not known if INFeD is safe and effective in children younger than 4 months of age. Before 0000011305 00000 n . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. INFeD should be used with caution in individuals with histories of significant allergies and/or asthma.
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